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Fabrication of highly modulable fibrous 3D extracellular microenvironments

Xixiang Zhang 1 - Personal Name
Fangfei Han 2 - Personal Name
Ahad Syed 3 - Personal Name
Ebtihaj M. Bukhari 4 - Personal Name
Basil Chew Joo Siang 3 - Personal Name
Shan Yang 1 - Personal Name
Bingpu Zhou 5 - Personal Name
Wei-jia Wen 5 - Personal Name
Dechen Jiang 2 - Personal Name

Three-dimensional (3D) in vitro scaffolds that
mimic the irregular fibrous structures of in vivo extracellular
matrix (ECM) are critical for many important biological ap-
plications. However, structural properties modulation of fi-
brous 3D scaffolds remains a challenge. Here, we report the
first highly modulable 3D fibrous scaffolds self-assembled by
high-aspect-ratio (HAR) microfibers. The scaffolds structural
properties can be easily tailored to incorporate various physi-
cal cues, including geometry, stiffness, heterogeneity and
nanotopography. Moreover, the fibrous scaffolds are readily
and accurately patterned on desired locations of the substrate.
Cell culture exhibits that our scaffolds can elicit strong

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Fabrication of highly modulable fibrous 3D extracellular microenvironments

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Subject(s)	PDMS Electrospinning 3D scaffolds 3D cell culture Fibrous scaffolds
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