Record Detail

Advanced Search

Text

Mini-review on initiatives to interfere with the propagation and clearance of alpha- synuclein in Parkinson’s disease

Daniel Kam Yin Chan 1,2,3* - Personal Name
Ying Hua Xu 1,2,3 - Personal Name
Luke Kar Man Chan 4 - Personal Name
Nady Braidy 1,2,3 and George D. Mellick 5 - Personal Name

In this mini-review, we summarize recent findings relating to the prion-like propagation of α-synuclein (α-syn) and
the development of novel therapeutic strategies to target synucleinopathy in Parkinson’s disease (PD). We link the
Braak’s staging hypothesis of PD with the recent evidence from in-vivo and in-vitro studies for the prion-like
cell-to-cell propagation of α-syn (via exocytosis and endocytosis). The classical accumulation of aggregated α-syn
in PD may result from an increased production or a failure in the mechanisms of clearance of α-syn. We discuss
novel agents, currently in clinical trial for PD including the ones that impact the aggregation of α-syn and others
that interfere with α-syn endocytosis as a means to target the progression of the disease.

File Attachment

Mini-review on initiatives to interfere with the propagation and clearance of alpha- synuclein in Parkinson’s disease

Availability

EB00000002378K Available

Detail Information

Series Title	-
Call Number	-
Publisher	: .,
Collation	-
Language
ISBN/ISSN	-
Classification	NONE
Content Type	-

Media Type	-
Carrier Type	-
Edition	-
Subject(s)	Parkinson’s disease aggregation α-synuclein Endocytosis
Specific Detail Info	-
Statement of Responsibility	-

Other version/related

No other version available

OPAC

RECORD DETAIL

Back To Previous

We have 41 news for you!

Hari Pustakawan: Pustakawan Lebih Dari Sekedar Menjaga Buku

2023-08-21 12:09:40

Masyarakat seringkali beranggapan bahwa Pustakawan hanya bertugas menata dan menajga buku, ataupun sekedar melayani pemustaka yang melakukan peminjaman buku, padahal peran pustakawan terus mengalami perluasan seiring dengan perkembangan jaman. Masifnya teknologi informasi menuntut Pustakawan untuk ...

Layanan Baru UPA Perpustakaan UNEJ: Open Class Literacy

2023-08-10 12:29:15

Dalam rangka mewujudkan fungsi edukasi perpustakaan, UPA Prpustakaan Universitas Jember menyediakan layanan kelas literasi bagi civitas akademika Universitas Jember yang memebutuhkan pelatihan terkait cara akses e-Resources yang dimiliki oleh Perpustakaan. Civitas akademika dapat melakukaan ...

MANUAL BOOK SISTER FOR STUDENT LIBRARY

2023-08-09 10:57:08

Panduan Sister For Student Aplikasi berbasis android yang dibuat oleh TIM UPA Teknologi Informasi Universitas Jember yang terintegrasi di SFS (Sister For Student), untuk memudahkan pemustaka atau pengguna dalam pencarian koleksi di katalog UPA Perpustakaan dan juga menu lainnya seperti Book...