Record Detail
Advanced SearchText
Mechanisms of L -Serine Neuroprotection in vitro Include ER Proteostasis Regulation
β-N-methylamino- L -alanine (L-BMAA) is a neu-
rotoxic non-protein amino acid produced by cyanobacteria.
Recently, chronic dietary exposure to L -BMAA was shown
to trigger neuropathology in nonhuman primates consistent
with Guamanian ALS/PDC, a paralytic disease that afflicts
Chamorro villagers who consume traditional food items con-
taminated with L -BMAA. However, the addition of the natu-
rally occurring amino acid L -serine to the diet of the nonhu-
man primates resulted in a significant reduction in ALS/PDC
neuropathology. L -serine is a dietary amino acid that plays a
crucial role in central nervous system development, neuronal
signaling, and synaptic plasticity and has been shown to im-
part neuroprotection from L -BMAA-induced neurotoxicity
both in vitro and in vivo. We have previously shown that L -
serine prevents the formation of autofluorescent aggregates
and death by apoptosis in human cell lines and primary cells.
These effects are likely imparted by L -serine blocking incor-
poration of L -BMAA into proteins hence preventing
proteotoxic stress. However, there are likely other mecha-
nisms for L -serine-mediated neuroprotection. Here, we ex-
plore the molecular mechanisms of L -serine neuroprotection
using a human unfolded protein response real-time PCR array
with genes from the ER stress and UPR pathways, and west-
ern blotting. We report that L -serine caused the differential
expression of many of the same genes as L -BMAA, even
though concentrations of L -serine in the culture medium were
File Attachment
Availability
EB00000002356K | Available |
Detail Information
Series Title |
-
|
---|---|
Call Number |
-
|
Publisher | : ., |
Collation |
-
|
Language | |
ISBN/ISSN |
-
|
Classification |
NONE
|
Content Type |
-
|
Media Type |
-
|
---|---|
Carrier Type |
-
|
Edition |
-
|
Subject(s) | |
Specific Detail Info |
-
|
Statement of Responsibility |
-
|
Other version/related
No other version available
OPAC
RECORD DETAIL
Back To Previous
Hari Pustakawan: Pustakawan Lebih Dari Sekedar Menjaga Buku
Masyarakat seringkali beranggapan bahwa Pustakawan hanya bertugas menata dan menajga buku, ataupun sekedar melayani pemustaka yang melakukan peminjaman buku, padahal peran pustakawan terus mengalami perluasan seiring dengan perkembangan jaman. Masifnya teknologi informasi menuntut Pustakawan untuk ...
Layanan Baru UPA Perpustakaan UNEJ: Open Class Literacy
Dalam rangka mewujudkan fungsi edukasi perpustakaan, UPA Prpustakaan Universitas Jember menyediakan layanan kelas literasi bagi civitas akademika Universitas Jember yang memebutuhkan pelatihan terkait cara akses e-Resources yang dimiliki oleh Perpustakaan. Civitas akademika dapat melakukaan ...
MANUAL BOOK SISTER FOR STUDENT LIBRARY
Panduan Sister For Student Aplikasi berbasis android yang dibuat oleh TIM UPA Teknologi Informasi Universitas Jember yang terintegrasi di SFS (Sister For Student), untuk memudahkan pemustaka atau pengguna dalam pencarian koleksi di katalog UPA Perpustakaan dan juga menu lainnya seperti Book...