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Prognostic values of the integrated model incorporating the volume of metastatic regional cervical lymph node and pretreatment serum Epstein–Barr virus DNA copy number in predicting distant metastasis in patients with N1 nasopharyngeal carcinoma

Ji‑Jin Yao - Personal Name
Zhen‑Yu Qi - Personal Name
Jun Ma - Personal Name
Zhi‑Bin Cheng - Personal Name
Li‑Zhi Liu - Personal Name
Li Li - Personal Name
Fan Zhang - Personal Name
Ya‑Nan Jin - Personal Name
Wang‑Jian Zhang - Personal Name
Si‑Yang Wang - Personal Name
Ya‑Qin Wang - Personal Name
Guan‑Qun Zhou - Personal Name
Ying Sun - Personal Name

Background: According to the 7th edition of the American Joint Committee on Cancer (AJCC) staging system, over
50% of patients with nasopharyngeal carcinoma (NPC) have N1 disease at initial diagnosis. However, patients with
N1 NPC are relatively under‑researched, and the metastasis risk of this group is not well‑stratifed. This study aimed to
evaluate the prognostic values of gross tumor volume of metastatic regional lymph node (GTVnd) and pretreatment
serum copy number of Epstein–Barr virus (EBV) DNA in predicting distant metastasis of patients with N1 NPC, and
to develop an integrated prognostic model that incorporates GTVnd and EBV DNA copy number for this group of
patients.

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Prognostic values of the integrated model incorporating the volume of metastatic regional cervical lymph node and pretreatment serum Epstein–Barr virus DNA copy number in predicting distant metastasis in patients with N1 nasopharyngeal carcinoma

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Subject(s)	Distant metastasis Nasopharyngeal carcinoma Lymph node volume Epstein–Barr virus DNA Prognostic model
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