UPA Perpustakaan Universitas Jember

Chemokine CCL27 is a novel plasma biomarker for identification the nasopharyngeal carcinoma patients from the Epstein-Barr virus capsid antigenspecific IgA seropositive population

Min-jie Mao - Personal Name
Ning Xue - Personal Name
Xue-ping Wang - Personal Name
Pei-dong Ch - Personal Name
Yi-jun Liu - Personal Name
Qi Huang - Personal Name
Shu-qin Dai - Personal Name
Wan-li Liu - Personal Name

Background: To investigate the predictive value of chemokine CCL27 for identifying early stage nasopharyngeal
carcinoma (NPC) patients within a population seropositive for Epstein-Barr virus (EBV) capsid antigen-specific IgA
(VCA-IgA).
Methods: CCL27 in plasma samples from 104 NPC patients, 112 VCA-IgA–positive healthy donors, and 140
VCA-IgA–negative normal subjects was measured by ELISA. Expression of CCL27 in nasopharyngeal tissue from
20 VCA-IgA–positive healthy donors and 20 NPC patients was examined by immunohistochemical staining.
Results: Levels of CCL27 in the plasma of VCA-IgA–positive healthy donors (607.33 ± 218.81 pg/ml) were significantly
higher than the levels in all NPC patients (437.09 ± 217.74, P = < 0.0001) and in the subset of patients with early stage
NPC (463.85 ± 226.17, P = 0.0126). Plasma CCL27 levels were significantly lower in the VCA-IgA–negative normal subjects
(358.22 ± 133.15 pg/ml) than in either the VCA-IgA–positive healthy donors (P < 0.0001) or the NPC patients (P = 0.0113).
CCL27 protein was detected in 16 of 20 (80%) nasopharyngeal tissue samples from VCA-IgA–positive healthy donors and
in 3 of 20 (15%) tumor tissue samples from NPC patients. There was no relationship between CCL27 levels and VCA-IgA
titers or plasma EBV DNA content. Receiver operating characteristic (ROC) curves demonstrated that plasma CCL27 levels
had a sensitivity of 67.00%, a specificity of 73.10%, and an area under the ROC of 0.725 (95% confidence interval [CI]: 0.
657–0.793) for distinguishing between NPC patients and VCA-IgA–positive healthy donors. Further analysis showed that
CCL27 levels could distinguish between early stage NPC patients and VCA-IgA–positive healthy donors with an area
under the ROC of 0.712 (95% CI: 0.560–0.865), a sensitivity of 59.80%, and a specificity of 84.60%.
Conclusions: Chemokine CCL27 could successfully identify NPC patients within a VCA-IgA–positive population.

No copy data

Detail Information

Series Title

Call Number

Publisher

: ,

Collation

Language

ISBN/ISSN

Classification

NONE

Detail Information

Content Type

Media Type

Carrier Type

Edition

Subject(s)

CCL27
VCA-IgA
Nasopharyngeal carcinoma
Early screening

Specific Detail Info

Statement of Responsibility

No other version available

UPA Perpustakaan

Merupakan Unit Pendukung Akademis (UPA) yang bersama-sama dengan unit lain melaksanakan Tri Dharma Perguruan Tinggi (PT) melalui menghimpun, memilih, mengolah, merawat serta melayankan sumber informasi kepada civitas akademika Universitas Jember khususnya dan masyarakat akademis pada umumnya.

VISI

UPA Perpustakaan Universitas Jember sebagai perpustakaan modern dengan layanan prima yang mampu menunjang visi Universitas Jember.

MISI

Menyelenggarakan pembinaan dan pengembangan ketersediaan bahan pustaka dan informasi ilmiah sesuai dengan kebutuhan pemustaka secara berkelanjutan

Meningkatkan kualitas dan sistem manajemen layanan perpustakaan secara professional dengan memanfaatkan teknologi informasi

Membina dan mengembangkan jaringan kerjasama dengan pusat-pusat informasi dan lembaga terkait dalam dan luar negeri

UPA Perpustakaan Universitas Jember

NPP. 3509212D1000001

Chemokine CCL27 is a novel plasma biomarker for identification the nasopharyngeal carcinoma patients from the Epstein-Barr virus capsid antigenspecific IgA seropositive population

Min-jie Mao - Personal NameNing Xue - Personal NameXue-ping Wang - Personal NamePei-dong Ch - Personal NameYi-jun Liu - Personal NameQi Huang - Personal NameShu-qin Dai - Personal NameWan-li Liu - Personal Name

Series Title

Call Number

Publisher

Collation

Language

ISBN/ISSN

Classification

Content Type

Media Type

Carrier Type

Edition

Subject(s)

Specific Detail Info

Statement of Responsibility

About Us

UPA Perpustakaan

LAYANAN DISTRIBUSI TUGAS AKHIR

Antrian Distribusi Tugas Akhir Hari ini : 0

MENUNGGU

0

PROSES

0

SELESAI

0

Statistik Distribusi Tugas Akhir

7 Hari Terakhir

per Fakultas

Total Koleksi

Total Item

Total Member

Total Pustakawan

Total Terpinjam

Peminjaman Tahun 2025

Peminjaman 5 Tahun

Peminjaman Bulan July 2025

Total Pengunjung

Pengunjung Tahun 2025

Pengunjung 5 Tahun Terakhir

Pengunjung Bulan July 2025

New collection + Update

Analisis Semiotika Roland Barthes: Visualisasi Kelas Sosial dalam Sinematografi Film the Handmaiden

Palang Merah Indonesia Kabupaten Jember dalam Penanganan Covid-19 di Kabupaten Jember Tahun 2020 - 2023.

Penggunaan Teknik Rule of Third dalam Pemahaman Isi Cerita pada Penciptaan Film Dokumenter Pae.

Telaah Kritis Film Indie Jember: Studi Distribusi Produk Kreatif Berbasis Digital

Eksistensi Radio Republik Indonesia Surabaya dalam Menyiarkan Program Pembangunan Pemerintah Orde Baru Tahun 1970-1998.

Penerapan Prinsip Kerja Sama pada Kegiatan Bahtsul Masa'il di Pondok Pesantren Darussalam Blokagung: Kajian Pragmatik

Aplikasi Android

Our Services

Help Desk and Service Support UPA Perpustakaan

Tautan Pintas :

Jam Layanan :

Senin - Kamis:

Jum'at:

Sabtu dan Minggu:

Alamat & Kontak Info :

Jalan Kalimantan No. 37 - Kampus Bumi Tegalboto Kotak POS 159 Jember, Jawa Timur, 68121, Indonesia

library@unej.ac.id

(+62) 331 333860

Min-jie Mao - Personal Name
Ning Xue - Personal Name
Xue-ping Wang - Personal Name
Pei-dong Ch - Personal Name
Yi-jun Liu - Personal Name
Qi Huang - Personal Name
Shu-qin Dai - Personal Name
Wan-li Liu - Personal Name