Atherosclerosis occurs in arterial curvatures and branches, where the flow is disturbed with low and
oscillatory shear stress (OSS). The remodeling and alterations of extracellular matrices (ECMs) and their composition
is the critical step in atherogenesis. In this study, we investigated the effects of different ECM proteins on the
regulation of mechanotransduction in vascular endothelial cells (ECs) in response to OSS.

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• Differential regulations of fibronectin and laminin in Smad2 activation in vascular endothelial cells in response to disturbed flow