In this research, an efficient procedure for the one-pot four-component
synthesis of 2H-indazolo[2,1-b]phthalazine-triones catalyzed by a cobalt-based
nanocatalyst (Co/Al2O3 nanocatalyst) is reported. The catalyst was prepared by a
co-precipitation method and characterized by BET surface area, SEM, TEM, EDS
and XRD analyses. A wide range of various aromatic aldehydes including electronwithdrawing
and electron-releasing groups were applied and corresponding products
obtained in high yields without any by-product. Moreover, the Co/Al2O3 is recyclable
up to 7 consecutive runs by simple filtration.

EB00000002694K

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• Cobalt‑based nanocatalyst catalyzed one‑pot four‑component synthesis 2H‑indazolo[2,1‑b] phthalazine‑triones under solvent‑free condition