Background: According to the 7th edition of the American Joint Committee on Cancer (AJCC) staging system, over
50% of patients with nasopharyngeal carcinoma (NPC) have N1 disease at initial diagnosis. However, patients with
N1 NPC are relatively under‑researched, and the metastasis risk of this group is not well‑stratifed. This study aimed to
evaluate the prognostic values of gross tumor volume of metastatic regional lymph node (GTVnd) and pretreatment
serum copy number of Epstein–Barr virus (EBV) DNA in predicting distant metastasis of patients with N1 NPC, and
to develop an integrated prognostic model that incorporates GTVnd and EBV DNA copy number for this group of
patients.

EB00000002137K

Available

• Prognostic values of the integrated model incorporating the volume of metastatic regional cervical lymph node and pretreatment serum Epstein–Barr virus DNA copy number in predicting distant metastasis in patients with N1 nasopharyngeal carcinoma