Vitamin D is one of the main groups of sterols; playing an important role in phospho-calcic metabolism. The conversion
of 7-dehydrocholesterol to pre- vitamin D3 in the skin, through solar ultraviolet B radiation, is the main source of vitamin
D. Since lupus patients are usually photosensitive, the risk of developing vitamin D defciency in is high in this population.
Although evidences showed the connotation between systemic lupus erythematosus (SLE) and vitamin D through which
SLE can lead to lower vitamin D levels, it is also important to consider the possibility that vitamin D defciency may have
a causative role in SLE etiology. This paper analyzes existing data from various studies to highlight the role of vitamin D
defciency in SLE occurrence and aggravation and the probable efcacy of vitamin D supplementation on SLE patients. We
searched “Science Direct” and “Pub Med” using “Vitamin D” and “SLE” for fnding the studies focusing on the association
between vitamin D defciency and SLE incidence and consequences. Evidences show that vitamin D plays an important role
in the pathogenesis and progression of SLE and vitamin D supplementation seems to ameliorate infammatory and hemostatic
markers; so, can improve clinical subsequent.

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