The current study sought to examine awareness of,
willingness to use, and preferences for available and theoret-
ical administration modalities for HIV pre-exposure prophy-
laxis (PrEP) and the association of anal sex roles with these con-
cepts among a sample of men who have sex with men (MSM) in
Paris, France. Broadcast advertisements were placed on a pop-
ular geosocial-networking smartphone application for MSM to
direct users to complete a Web-based survey. MSM answered
questions on their recent engagement in condomless anal inter-
course and awareness of and willingness to use PrEP in the form
of once daily and event-driven pill regimens, long-acting injec-
tions, and penile and rectal microbicides as well as sexual roles.
Multinomial regression models were fit to assess the association
between behaviorally classified anal sexual role and preferences
for one of these biomedical prevention modalities. A total of 482
HIV-uninfected MSM completed the survey, 48.1% of whom
engaged in some form of condomless anal intercourse in the pre-
ceding 3 months. Most respondents (85.3%) had heard of once
daily PrEP, but fewer respondents had heard of other prevention
strategies. Assuming equal effectiveness, long-acting injections
were the most commonly preferred (21.8%). Behaviorally defined
‘‘bottom’’and‘‘versatile’’MSMmorefrequentlypreferredlong-act-

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• Are Anal Sex Roles Associated with Preferences for Pre-Exposure Prophylaxis Administration Modalities Among Men Who Have Sex with Men?