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UPA Perpustakaan Universitas Jember

Biocontractile microfluidic channels for peristaltic pumping

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Bio-actuated micro-pumps do not need any exter-
nal power source and pose no risk of electrical or heat shock
for the biological materials in lab-on-chip systems. Several
different designs of bio-actuated micro-pumps based on the
use of the contractile force of cultured cardiomyocites have
been proposed earlier. Here we present a novel type of a bio-
actuated micro-pump representing a microfluidic channel with
a contractile wall. The flow inside the channel is generated by
the peristaltic movement of its wall caused by the propagation
of an excitation-contraction wave along the channels surface.
The directional flow generated by the pump was demonstrated
by tracking of polystyrene microspheres, moving in the direc-
tion of the propagation of the excitation-contraction wave with
an average velocity of 6–8 μm/min. The suggested design of a
micro-pump allows the control of pumping direction, which
might be useful for targeted delivery of fluids and substances
in lab-on-chip systems. Prospects of future development and
implementation of this kind of bio-actuated peristaltic pumps
are discussed.

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