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UPA Perpustakaan Universitas Jember

NMDAR LTP and LTD induction: 2B or Not 2B... is that the question?

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NMDA receptor (NMDAR) dependent forms of
synaptic plasticity are thought to play critical roles in many
aspects of CNS function and dysfunction, from learning and
memory to addiction. NMDARs are heteromeric tetramers
principally comprised of two NR1 subunits and two of four
varieties of NR2 subunits (NR2A-2D). Recently, it has been
proposed that specific NR2 subtypes subserve distinct roles
in NMDAR-dependent long-term potentiation (LTP) and
long-term depression (LTD). Here, we will review this
literature, and describe an existing countervailing hypothesis, the charge-transfer hypothesis, which postulates that the
total charge transfer through NMDARs, rather than specific
subunits, dictates the polarity of synaptic plasticity. We will
propose that a modification of the charge-transfer hypothesis, to include the possible involvement of protein-protein
interactions imparted by distinct NR2 subunits, best fits the
existing data.

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