Presented here is an efcient one-pot and catalyst-free procedure for
the synthesis of amides starting from carboxylic acids and amine/ammonium salts
using 2,2-dichloro-1,3-diisopropylimidazolidine-4,5-dione as the coupling agent.
Reactions can proceed smoothly even with those bearing thermosensitive group(s)
at ambient temperature, and the corresponding products of primary, secondary and
tertiary amides can be aforded in moderate to excellent yields of up to 96%.

• An efcient procedure for chemoselective amidation from carboxylic acid and amine (ammonium salt) under mild conditions