HSF1 (heat shock factor 1) is a transcription factor that is found to facilitate malignant cancer development
and proliferation. In cancer cells, HSF1 mediates a set of genes distinct from heat shock that contributes to malignancy.
This set of genes is known as the HSF1 Cancer Signature genes or simply HSF1-CanSig genes. HSF1-CanSig genes
function and operate differently than typical cancer-causing genes, yet it is involved in fundamental oncogenic processes.

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• Overexpressed HSF1 cancer signature genes cluster in human chromosome 8q