Despite the fact that some progress has been made in the self-assembly of H-shaped polymers, the corresponding self-assemblies
that respond to external stimulus and are further utilized to adjust the release of drugs are still deficient. The stimuli-responsive segments
with amphiphilic H-shaped structure are generally expected to enhance the controllability of self-assembly process. The synthesis and
self-assembly behavior of thermo-responsive amphiphilic H-shaped polymers with poly(ethylene glycol) (PEG), polytetrahydrofuran
(PTHF) and poly(N-isopropyl acrylamide) (PNIPAM) as building blocks are reported in this paper. The inner architecture structure and size
of complex micelles formed by H-shaped self-assemblies were effectively adjusted when the solution temperature was increased above the
lower critical solution temperature of PNIPAM segments. Furthermore, it was found that the architecture of self-assemblies underwent a
transition from the complex micelles based on primary micelles with hybrid PEG/PNIPAM shells to large complex micelles based on
primary micelles with hybrid PTHF/PNIPAM cores and PEG shells during the thermal-induced self-assembly process. The adjustable
release rate of doxorubicin (DOX) from the DOX-loaded complex micelles and basic cell experiments further proved the feasibility of these
self-assemblies as the thermal-responsive drug delivery system.

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• Controlled Self-assembly of Thermo-responsive Amphiphilic H-shaped Polymer for Adjustable Drug Release