A better hygiene, a Westernized diet, air pollution, climate changes, and other factors that influence host microbiota, a
key player in the induction and maintenance of immunoregulatory circuits and tolerance, are thought to be responsible
for the increase of allergic diseases observed in the last years. The increase of allergic diseases in elderly is related to the
presence of other factors as several comorbidities that should interfere with the development and the type of allergic
reactions. A central role is played by immunosenescence responsible for modifying response to microbiota and triggering
inflamm-ageing. In addition, in elderly there is a shift from Th1 responses vs. Th2, hence favouring allergic responses.
Better understanding of the mechanisms of immunosenescence and its effects on allergic inflammation will most
certainly lead to improved therapy.

EB00000003186K

Available

• Immunological and non-immunological mechanisms of allergic diseases in the elderly: biological and clinical characteristics