Breast reduction surgery is a common procedure
and the rate of incidental findings in the removed specimens
varies between 0% and 4.6%. There are no guidelines about
pathological evaluation of breast reduction surgery. We
reviewed all pathology reports of patients undergoing breast
reduction surgery in a single tertiary institution in Brazil from
January 2008 to August 2014. Exclusion criteria were a per-
sonal history of breast cancer, unclear reason for mastectomy
and incomplete data on the pathology report. We considered
Brelevant findings^ flat epithelial atypia, atypical hyperplasia,
carcinomas in situ and invasive carcinoma. Of 1672 speci-
mens from breast reduction surgery, 783 met inclusion
criteria. Median patient age was 40 (8–77), 91% underwent
bilateral mastectomy and 57% of the specimens weighted less
than 200 g. In 55% of cases, 4 or more paraffin blocks were
sampled. There were 40 (5.1%) relevant findings and the most
common was atypical lobular hyperplasia (16–2%). There
were 3 invasive carcinomas (0.38%). In multivariate analysis,
the only variables associated with a higher odds of relevant
pathological findings were patient age ≥ 40 (OR 4.73 CI95%
1.98–11.3 p < 0.001) and sampling of ≥4 paraffin blocks from
each specimen (OR 6.69 95% CI 2.25–19.9 p < 0.001). The

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• Incidental Findings in Reduction Mammoplasty Specimens in Patients with No Prior History of Breast Cancer. An Analysis of 783 Specimens